Localization of epitopes for human factor VIII inhibitor antibodies by immunoblotting and antibody neutralization
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چکیده
منابع مشابه
Localization of epitopes for human factor VIII inhibitor antibodies by immunoblotting and antibody neutralization.
Human factor VIII(FVIII) inhibitors are pathologic, circulating antibodies that inactivate FVIII. We have examined the location of epitopes on the FVIII protein for inhibitors from hemophilia A and nonhemophilic individuals. The inhibitors were of type I or type II in the kinetics of their inactivation of FVIII. A cDNA clone of human FVIII was used to express defined FVIII protein fragments in ...
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Anti-human factor VIII C2 domain antibodies in hemophilia A mice recognize a functionally complex continuous spectrum of epitopes dominated by inhibitors of factor VIII activation Short title: Anti-factor VIII C2 domain antibody epitopes Shannon L. Meeks, John F. Healey, Ernest T. Parker, Rachel T. Barrow and Pete Lollar Aflac Cancer Center and Blood Disorders Service, Children’s Healthcare of ...
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ژورنال
عنوان ژورنال: Blood
سال: 1989
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v74.5.1618.1618